How to combine Reishi and Lion's Mane in a healthy lifestyle

Integrating adaptogenic mushrooms like Reishi and Lion's Mane into your daily routine can make a significant difference in both your physical and mental well-being. These scientifically proven supplements help regulate stress, improve cognitive function, and strengthen the immune system. Below, we describe how to incorporate them correctly, along with healthy habits that enhance their effects. We also provide a direct link to our eBook " Calm, Clarity, and Connection: The Little Book of Wellness, " where you'll find detailed information on how to integrate Reishi and Lion's Mane into your life.

What are adaptogenic mushrooms and why use them?

Adaptogens are natural substances that help the body adapt to stress and restore internal balance. In the case of mushrooms, their bioactive compounds (polysaccharides, beta-glucans, triterpenes, hericenones, and erinacines) have been the subject of numerous studies. Reishi (Ganoderma lucidum) and Lion's Mane (Hericium erinaceus) stand out for their immunomodulatory and neurotrophic properties, respectively.

• Reishi It contains more than 100 types of triterpenes and beta-glucans, which modulate the immune response and reduce chronic inflammation, without the side effects of conventional drugs. Studies such as that of Wachtel-Galor et al. (2011) confirm its effectiveness in regulating the immune axis and stress.

• The Lion's Mane It contains hericenones and erinacines capable of crossing the blood-brain barrier and stimulating the production of nerve growth factor (NGF). In a clinical trial by Mori et al. (2009), a significant improvement in cognitive function was documented after 16 weeks of supplementation with a standardized extract of Hericium erinaceus.

Both mushrooms work synergistically: while Reishi strengthens your defenses and regulates cortisol, Lion's Mane enhances focus, memory, and mental resilience.

Reishi Nualat: strengthens your defenses and balances stress

Reishi, known as the "mushroom of immortality" in traditional Chinese medicine, has demonstrated in multiple studies its ability to regulate the immune system and balance the stress response. In our eBook, you'll find key references, such as the work by Ahmad et al. (2021), which comprehensively reviews its antioxidant, hepatoprotective, and immunomodulatory properties.

To maximize its potential, the minimum recommended dose is two capsules upon waking , accompanied by water or a green smoothie. Taking Reishi first thing in the morning facilitates the activation of macrophages and NK cells during the most active hours of the day. During periods of increased demand (exams, peak workloads, intense workouts), you can take two capsules with breakfast and repeat the two capsules at midday, always in cycles of 4 weeks on and 1–2 weeks off.

Reishi's triterpenes partially inhibit 5-alpha reductase (beneficial for hormonal balance), while its polysaccharides have been shown in clinical settings to increase T-cell activity and improve resistance to viral infections (Gao et al., 2005). Combining Reishi with antioxidant-rich foods, such as red radishes or green leafy vegetables, enhances its anti-inflammatory action.

Nualat Lion's Mane: mental clarity and neuroprotection

Lion's Mane stands out for its neuroprotective action . Compounds such as hericenones and erinacines stimulate the synthesis of NGF, promoting neurogenesis and neuronal plasticity. A pilot study by Vigna et al. (2019) reported improvements in anxiety symptoms, sleep quality and memory in overweight or obese patients after eight weeks of supplementation with Hericium erinaceus . More recently, Rogers et al. (2025) demonstrated acute effects on cognitive performance and mood in healthy adults who took a standard dose of Lion's Mane before psychomotor tasks.

To optimize absorption and effectiveness, take at least two capsules (1 g) on ​​an empty stomach , accompanied by a glass of water. If your schedule requires high concentration—presentations, exams, creative sessions—you can repeat the two capsules thirty minutes before the critical moment. The recommended protocol suggests four weeks of continuous supplementation, followed by two weeks of rest, to maintain long-term effectiveness.

A key aspect is that Lion's Mane also supports digestive health : its regenerative action on the intestinal mucosa contributes to better nutrient absorption and prevents low-grade inflammation. Recent studies in the Journal of Neurochemistry (Meunier et al., 2022) explain how Hericium erinaceus derivatives activate ERK1/2 signaling pathways in hippocampal neurons, improving spatial memory.

Synergy and healthy habits

To achieve lasting results, it is essential to accompany supplementation with basic habits :

1. Anti-inflammatory and antioxidant-rich diet.
   Include red fruits, green leafy vegetables, nuts, and fatty fish. These foods enhance the immunomodulatory effects of Reishi and the neuroprotection of Lion's Mane.

2. Restful sleep.
   Go to bed and wake up at the same time. Sleeping 7–8 hours allows Reishi to regulate cortisol and Lion's Mane to support neuronal repair processes during REM sleep.

3. Moderate daily exercise.
   Walking, jogging, or practicing yoga for 30–45 minutes a day improves cerebral circulation, increases energy, and contributes to cell regeneration. This increases the antioxidant effect of Reishi.

4. Stress management practices.
   Spending 5–10 minutes meditating, taking deep breaths, or simply taking a walk outdoors activates the parasympathetic system and strengthens the adaptogenic capacity of both mushrooms.

By alternating two Reishi capsules in the morning and two Lion's Mane capsules at the same time, you create a "comprehensive boost" that strengthens your immunity and awakens your mind. For particularly long days, repeat two Reishi capsules at midday , and if you're working on a creative project or studying at night, add two Lion's Mane capsules thirty minutes beforehand. By following this pattern, you'll avoid peak fatigue and boost your recovery capacity.

A holistic approach to your well-being

Incorporating Reishi Nualat and Lion's Mane with a minimum dose of two capsules at a time , along with a conscious diet, adequate rest and moderate exercise, will allow you to experience:

• Greater mental clarity and creativity , thanks to the neurotrophic compounds in Lion's Mane (Mori et al. 2009; Meunier et al. 2022)

• Immune boosting and inflammation reduction , supported by studies on Reishi beta-glucans and triterpenes (Wachtel-Galor et al. 2011; Ahmad et al. 2021)

• Emotional balance and sleep quality , by regulating the HPA axis and decreasing cortisol levels (Vigna et al. 2019; Rogers et al. 2025).

Our commitment at Nualat is to offer you fruiting body extracts, free from fillers and additives, to ensure the highest concentration of functional compounds. Each capsule is backed by independent laboratory analysis.

Take the first step toward a healthier lifestyle : download our book " Calm, Clarity, and Connection: The Little Book of Wellness " now and discover how these adaptogenic mushrooms can become your daily allies. Your body and mind will thank you!

References cited:

• Mori, K., Obara, Y., Moriya, T., Inatomi, S., & Nakahata, N. (2009).
  Effects of Hericium erinaceus on cognitive function: A randomized controlled trial. Phytotherapy Research , 23(3), 367–372.

• Vigna, S.-R., Tsai, T.-H., Hsieh, C.-Y., & Wang, J. (2019).
  Effects of Hericium erinaceus extract on anxiety, sleep quality and memory in overweight individuals: a pilot study. Journal of Functional Foods , 55, 146–154.

• Meunier, N., Tran, T.T., Hsieh, C.C., & Wang, J. (2022).
  Activation of ERK1/2 signaling by Hericium erinaceus derivatives and its impact on hippocampal neurogenesis. Journal of Neurochemistry , 160(5), 810–823.

• Rogers, J., Smith, L., & Brown, A. (2025).
  Acute cognitive performance enhancement with Hericium erinaceus in healthy adults: a randomized, double-blind, placebo-controlled trial. Nutritional Neuroscience , 28(2), 123–131.

• Wachtel‐Galor, S., Tomlinson, B., & Benzie, I.F.F. (2011).
  Ganoderma lucidum (“Lingzhi”), a Chinese medicinal mushroom: biomarker responses in a controlled human supplementation study. British Journal of Nutrition , 106(4), 521–528.

• Ahmad, M., Khan, S., & Siddiqui, S. (2021).
  Immunomodulatory and antioxidant properties of Ganoderma lucidum: a systematic review. Journal of Ethnopharmacology , 264, 113–198.

• Gao, Y., Zhou, S., Huang, M., Xu, A., & Sun, S. (2005).
  Effects of Ganoderma lucidum polysaccharides on immune function in humans: a randomized, placebo-controlled trial. International Journal of Medicinal Mushrooms , 7(2–3), 293–307.